Bet365 Bonus Code: Bet $10, Get $365 Win or Lose on Thursday Night Football, Bills vs Lions
Josh Allen of the Buffalo Bills runs for a touchdown against the Houston Texans in the second quarter at NRG Stadium on Sept. 13, 2026, in Houston, Texas. (Getty Images)
Years ago, before the sponsored games and different streaming partners, Thursday Night Football had some of the weaker matchups on a slate. Over the past few years, the games have featured some of the best players and teams. This Thursday is no exception, as we get the Bills against the Lions.
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There are plenty of options for things to bet on in this game. The Lions have one of the most versatile offenses in football. Jahmyr Gibbs is one of the best running backs in the game, and the team has positioned him to be a three-down back. In his first game, he showcased his skills by running for two touchdowns. He also racked up 156 yards on 29 carries.
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The Bills don’t have quite as many big-name options on offense, but they do have Josh Allen running the show. Allen’s full skill set was on display against the Texans in Week 1. He ran the ball for two touchdowns, including the first one of the season for the squad. He also threw for 334 yards against a tough defense. Now he is licking his chops against a team that struggled mightily late in the game against the Saints.
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Lions vs. Bills
*Odds are subject to change*
| Team | Spread | Total | Moneyline |
| Lions | +4.5 (-102) | O 54.5 (-110) | +190 |
| Bills | -4.5 (-118) | U 54.5 (-110) | -230 |
How to Watch Lions vs. Bills
- When: Thursday, Sept. 17, 2026, 8:15 ET
- Where: Highmark Stadium, Orchard Park, NY
- TV/Streaming: Prime Video
Player Comparison
| Player | Completions | Attempts | Yards | Touchdowns |
| Jared Goff | 26 | 39 | 206 | 2 |
| Josh Allen | 20 | 29 | 334 | 2 |
| Player | Rushes | Yards | Touchdowns |
| Jahmyr Gibbs | 29 | 156 | 2 |
| Josh Cook | 13 | 57 | 0 |
| Player | Catches | Yards | Touchdowns |
| Amon-Ra St. Brown | 10 | 67 | 2 |
| Dalton Kincaid | 5 | 130 | 0 |
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