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Thursday, October 8, 2026

Iowa State vs. BYU prediction, odds, time: Week 6 college football Friday picks from proven model

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SportsLine's model revealed its best bets for the Friday Big 12 Conference matchup between the Iowa State Cyclones and BYU Cougars

• 2 min read

The eighth-ranked BYU Cougars will look to stay unbeaten when they battle the visiting Iowa State Cyclones in a key Big 12 Conference matchup on Friday night. Iowa State is coming off a 45-42 win over West Virginia on Saturday, while BYU held off TCU 17-10. The Cyclones (3-2, 1-1 Big 12), who are 0-2 against ranked opponents, are 0-1 on the road this season. The Cougars (4-0, 2-0 Big 12), who have outscored their opponents 149-57, are 2-0 on their home field. Visit our Kalshi promo code review and get a $55 bonus after $25+ in trades with the Kalshi promo code CBSSPORTS55:

Kickoff is set for 10:15 p.m. ET at LaVell Edwards Stadium in Provo, Utah. Iowa State leads the all-time series 5-1, but BYU won last year's meeting in Iowa. The Cougars are 10.5-point favorites, with the over/under at 46.5 in the latest Iowa State vs. BYU odds. Before making any BYU vs. Iowa State picks, check out the Iowa State vs. BYU predictions from the SportsLine Projection Model. 

Iowa State vs. BYU odds

Iowa State vs. BYU spread

BYU -10.5

Iowa State vs. BYU over/under

46.5 points

Iowa State vs. BYU money line 

BYU -410, Iowa State +320

Iowa State vs. BYU picks

See picks at SportsLine

Iowa State vs. BYU streaming 

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Top BYU vs. Iowa State predictions

After simulating Iowa State vs. BYU 10,000 times, SportsLine model is going Over 46.5 points at betting apps. The Under has hit in six of the past nine Iowa State games. The Under is 6-4 over the past 10 BYU games, including two of the past three at home.

Senior quarterback Jaylen Raynor helps power the Cyclones' offense. So far this season, he has completed 58% of his passes for 903 yards and six touchdowns with four interceptions. Sophomore quarterback Bear Bachmeier leads the BYU attack. He has completed 64% of his passes for 704 yards and six touchdowns with one pick. He has also rushed 27 times for 130 yards (4.8 average) and four touchdowns.

SportsLine's model is projecting 52 combined points in this one, making the Over the value 56% of the time. See the model's spread and money-line picks at SportsLine.

How to make Iowa State vs. BYU picks

In addition to going Over on the total, the model also says one side of the spread has all the value. You can only get the pick at SportsLine. 

So who wins Iowa State vs. BYU, and which side of the spread has all the value? Visit SportsLine now to see which side of the BYU vs. Iowa State spread to jump on, all from the advanced model that's on a 40-35 run on top-rated CFB picks, and find out.

Why you should trust SportsLine's model

The model simulates every FBS game 10,000 times. It entered Week 6 on a profitable 40-35 run on all top-rated college football picks at betting sites. Anybody following its picks on college football betting sites could have seen strong returns. 

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Iowa State vs. BYU prediction, odds, time: Week 6 college football Friday picks from proven model — KioskNews