‘Grey’s Anatomy’ Texas Spinoff Casts ‘How to Get Away With Murder’ Alum Karla Souza in Lead Role

The “Grey’s Anatomy” spinoff set in West Texas has cast Karla Souza in a lead role, Variety has learned.

The spinoff was originally announced at ABC in May. It was intended to launch during the 2026-2027 broadcast season, but was recently delayed to the 2027-2028 season after it did not receive a California TV tax credit.

The official logline for the untitled series describes it as “an edgy drama about a team at a West Texas rural medical center — the last chance for care before miles of nowhere.”

Souza will star as Dr. Carolina “Lina” Hall, who is described as “a haunted and cynical doctor who runs a medical center in a small town in West Texas.”

The role brings Souza back into the ABC and Shondaland fold. She previously starred in the Emmy-winning ABC series “How to Get Away With Murder” in the role of Laurel Castillo. She also starred in the ABC sitcom “Home Economics,” which aired for three seasons. Souza’s other credits include “Day Shift” at Netflix, the series “56 Days” and the film “La Caida” at Amazon, with Souza winning an International Emmy Award for the film, and the Mexican films “¿Qué culpa tiene el niño?,” “Nosotros los Nobles,” and “Instructions Not Included.”

She is repped by Gersh, Untitled, and Gang Tyre.

Shonda Rhimes and Meg Marinis are the co-creators and executive producers on the spinoff series. “Grey’s Anatomy” star Ellen Pompeo is also an executive producer, as is Betsy Beers. 20th Television and Shondaland produce.

This will now be the third spinoff of “Grey’s Anatomy.” In addition to the mothership show, ABC has also aired the spinoffs “Private Practice” and “Station 19,” which ran for six seasons and seven seasons respectively. ABC also aired the digital series “Grey’s Anatomy: B-Team” on ABC.com in 2018.