Tearful Christina Applegate Says She Was Misdiagnosed With MS
Jamie-Lynn Sigler Shares Update on Christina Applegate Amid Health Concerns
Christina Applegate is left with more questions than answers about her health.
More than five years after the Married… with Children alum spoke out about her battle with multiple sclerosis, she learned that she was misdiagnosed.
"This may come as great news, but to me it comes as, like, I'm back at square one," Applegate said on the Oct. 20 episode of her and Jamie-Lynn Sigler's MeSsy podcast. Recalling her doctor's visit, she added, "She came into my room and said, 'Congratulations, you don't have MS.' I was, like, not happy at all. Everybody else was so happy."
The 54-year-old emphasized that the confirmation of the misdiagnosis hadn't changed how she's continued to struggle physically, still regularly using a walking cane and experiencing pain and aches all over her body.
"I haven't gotten better, Jamie," she said. "If anything, I've gotten worse. So I'm back at square one where I don't know what's going on with me. That's going to be an online investigation that my doctors are going to be getting into just to find out what has been going on since 2021."
"I have every symptom of someone with MS," she continued. "Every single one. Now, we both know that there are many things that mirror MS. Many different things."
Applegate—mom to 15-year-old daughter Sadie with husband Martyn LeNoble—shared insight into her mental health struggles after learning that she does not have the degenerative chronic autoimmune disorder.
"I'm sitting here having slept all day yesterday feeling like absolute crap because of the heat," she said. "My legs aren't working. All the same stuff is happening to me. And yet I have this thing of like, 'Well, you don't have that, so maybe you're faking it' in my head."
The Dead to Me actress admitted that she also feels guilty since she had found immense support among others suffering from MS.
Emma McIntyre/Getty Images for SiriusXM
"I leaned into other friends," she noted. "I leaned into the community. I felt safe because I had a place to talk, which was here felt like, 'OK, I have an answer. What a great thing. I may not get out of this. I might get worse, but I'm taking all the necessary precautions.'"
"It's weird because I feel like I let everybody down," Applegate shared. "It's this weird feeling because I became this, you and I: the poster children for MS. Everything I was doing, I had a reason. I had a f--king reason as to why my day sucked every day. And now I don't have a reason. It's very unnerving, and it's very confusing for me."
Sigler—who was diagnosed with MS in 2002 at age 20 while working on The Sopranos—empathized with Applegate's frustrations.
Monica Schipper/WireImage
"It brings up an interesting point that we can talk about," she said, "the labeling of things and how attached we become to them for so many reasons. It feels like there's a road map, at least, that you have for things."
"We've come to learn that this is not a rare occurrence," Sigler continued of medical misdiagnoses, "especially when it comes to MS."
A 2019 study led by Cedars-Sinai found that nearly one in five patients with "an established diagnosis" were misdiagnosed.
Sigler, 45, also urged her co-host not to feel as if she's at fault for her current situation.
"Everything you did and shared and were and are to so many people doesn't go anywhere," she added. "This new information that you have in your life, that doesn't take away anything that you did. You didn't mislead anyone."
As Applegate continues her journey to find an answer, keep reading for a look back at what she had shared about her health battle.
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Health Journey
Christina Applegate shared she was diagnosed with multiple sclerosis in 2021.
"Hi friends. A few months ago I was diagnosed with MS," she shared on her social media channels that August. "It's been a strange journey. But I have been so supported by people that I know who also have this condition. It's been a tough road. But as we all know, the road keeps going. Unless some a--hole blocks it."
Stewart Cook/Shutterstock
First Public Appearance
"Oh, by the way, I have a disease," she joked during her November 2022 Hollywood Walk of Fame induction ceremony, her first public appearance since her MS diagnosis. "Did you not notice? I'm not even wearing shoes."
Daniele Venturelli/WireImage
Early Symptoms
Applegate believes her MS journey actually began "six or seven years" before her 2021 diagnosis.
"I noticed, especially the first season [of Dead to Me], we'd be shooting and my leg would buckle," Applegate explained during a March 2024 interview on Good Morning America. "I really just put it off as being tired, or I'm dehydrated, or it's the weather. Then nothing would happen for months, and I didn't pay attention."
By the time she was shooting the Netflix series' third and final season, the actress said she was "being brought to set in a wheelchair."
"I couldn't move that far," she recalled, "so I had to tell everybody because I needed help."
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Making Moves
The Dead to Me star captioned this photo of her cane collection amid her battle with MS: "Walking sticks are now part of my new normal."
Matt Baron/BEI/Shutterstock
Strong Statement
Joined by her daughter Sadie Grace LeNoble, Applegate had a simple message for multiple sclerosis while attending the 2023 SAG Awards: "F U MS."
And she's not the only one experiencing strong feelings towards the illness. "In my situation, Sadie only knew me as healthy and a runner and a Pelotoner and a dancer—and she only knew that," Applegate explained to friend Jamie-Lynn Sigler on an August 2025 episode of their MeSsy podcast. "So then when this came about in 2021, she was, like, stoic about it."
Yet, "I see her look at me when I’m in bed," Applegate continued, "and can't quite move or, I want to go say goodnight to her in her room but I can’t quite get down the hallway for whatever reason my legs aren’t working that day."
The whole experience has "broken" her teen, Applegate noted. "It was like losing the mom she had to this f--king thing. And the more she’s gotten older now, I think the more it’s hurting her."
Kevin Winter/Getty Images
Just Jokes
After a receiving standing ovation at the 2023 Emmys, the Married...With Children alum quipped, "You're totally shaming me with disability by standing up."
Matt Winkelmeyer/Getty Images for Critics Choice Association
Healing Through Humor
"I make these jokes because if I don't, I'll suffocate," Applegate shared on a March 2024 episode on Armchair Expert, explaining why she often pokes fun at her condition. "I'll be done."
So, yes, she's going to talk about the fact that she's already purchased burial plots.
"My friend and I are going to go take a picnic there," Applegate revealed on a March 2026 episode of NPR's Wild Card. "It's really pretty where it is." She just has to pick out a tree "'cause it's really sunny," she continued. "And I want my visitors to not be sweating."
Kevin Mazur/Getty Images for Critics Choice Association
MS On Her Mind
"I have 30 lesions on my brain," she noted on Armchair Expert. "My biggest one is behind my right eye, so my right eye hurts a lot."
Legions are caused by the immune system attacking the myelin sheath around nerves, according to the Multiple Sclerosis Trust.
Randy Holmes/Disney via Getty Images
Getting Candid
Applegate hasn’t held back when it comes to sharing her journey.
"It sucks," the Anchorman actress told late night talk show host Jimmy Kimmel of her daily struggles with MS. "I'm not going to lie. I think anyone who has MS isn't going to be like, 'This is the best thing that ever happened to me!'"
Besides, she'd taken that tack when discussing her breast cancer battle back in 2008. "I went out, and I was the good girl talking about 'Oh, I love my new boobs' that are all scarred and f--ked up. What was I thinking?" she said on Armchair Expert. "Everything I was saying was a freaking lie. It was me trying to convince myself of something, and I think that did no service to anyone."
While she started a foundation and "raised millions of dollars for women to get MRIs who were at high risk," she noted, "at the back of it, I was taking off my bra and crying every night. And I wish that I had said that."
Monica Schipper/WireImage
In Her Bubble
When talking about her day-to-day life with the disease, Applegate told Good Morning America in March 2024, "I live kind of in hell."
"But I might get to a place where I function a little bit better," she added. "Right now, I'm isolating, and that's kind of how I'm dealing with it—by not going anywhere because I don't want to do it. It's hard."
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The Sweetest Support
Christina credited her Sweetest Thing costar Selma Blair—who was diagnosed with MS in 2018—for urging her to get tested for the disease.
"She said, 'You need to get checked for MS,'" Christina recalled during her GMA interview. "If not for her, it could've been way worse."
Phillip Faraone/Getty Images
Friendship Never Dies
Applegate confirmed that Dead to Me will likely be her last onscreen credit, telling Vanity Fair in May 2023, "I can’t even imagine going to set right now."
"I’m probably not going to work on-camera again, but I'm so glad that I went out with someone who is by far the greatest actress I’ve ever worked with in my entire life," she said of costar Linda Cardellini, "if not the greatest human I’ve ever known.
Charles Sykes/Bravo; Emma McIntyre/Getty Images for Netflix
The Dirty Truth
For Applegate, contracting sapovirus—a virus commonly transmitted through fecal-oral contact—meant having to rely on adult diapers.
"I woke up at three o'clock in the morning in a pool of s--t," she explained on an April 2024 episode of her MeSsy podcast. "I didn't know what happened, and having MS at three o'clock in the morning and trying to change your sheets, it's not fun. But this brings me to my next point, which we can talk about: I'm wearing diapers."
Their discussion was "so liberating," her co-host Sigler noted. "This is something you do by yourself and it feels terrible when you're doing it. I've done that hundreds of times in my MS journey through the years when I've experienced a flair or when I was sick."
Christina Applegate/Instagram
Dark Matter
"I am in a depression right now, which I don't think I've felt for years," Applegate confessed to Sigler on another 2024 episode of their MeSsy podcast. "Like a real, f--k it all, like real depression where it's kind of scaring me too a little bit because it feels really fatalistic."
Three years into her diagnosis, she continued, "And I'm still sitting here like ‘Boohoo, woe is me.' I'm still mad about it." But the truth was, added, "I don't enjoy living—I don't enjoy things anymore."
Tibrina Hobson/WireImage
Screaming Pain
Applegate acknowledged the reality of living with MS can be grim. “Everybody has different ways of it showing up,” she noted on a November 2024 episode of her podcast. "I lay in bed screaming. Like, the sharp pains, the ache, the squeezing."
At times, the discomfort even makes it hard for her to enjoy her one source of comfort, the reality TV that at times is "on 24/7 in my room," she noted. But, "I can’t even pick up my phone sometimes," Applegate added, "because now it’s traveled into my hands. So I’ll try to go get my phone or get my remote to turn on the TV or whatever, and sometimes I can’t even hold them."
Kevin Winter/Getty Images
Checking In
Since her 2021 diagnosis, Applegate has gotten used to the feel of an open-front gown. "I've been in the hospital upwards of 30 times from throwing up and diarrhea and pain," she relayed on her pocast in March 2025. "That is unimaginable, OK? They’ve done every test known to man on me, put so much radiation into my body from CT scans to everything else."
In the plus column, she noted, she has connected some of her gastro issues to her larger illness. "I have noticed that—and I’m going to be really honest—if I have to poop, I puke," she detailed. "And when I puke, I get all the pain and then all the things happen."
Mere months after her hospital confession, Applegate was checking back in. Returning from a family trip to Europe, "I'm like, 'I wanna be admitted. I'm staying here because I want answers,'" she recounted that August of what she told staff. "'I want every test that you can possibly think of or ones that you haven't even thought of, and I want them done.'"
Following a middle-of-the-night CT, she learned, "I had kidney infections."
Emma McIntyre/Getty Images for SiriusXM
Back to Square One
More than five years after sharing her battle with multiple sclerosis, she learned that she was misdiagnosed.
"She came into my room and said, 'Congratulations, you don't have MS,'" she recalled of her doctor's visit in the October 2026 podcast MeSsy. "I was, like, not happy at all. Everybody else was so happy."
Applegate emphasized that the confirmation of the misdiagnosis hadn't changed how she's continued to struggle physically.
"I haven't gotten better," she said. "If anything, I've gotten worse. So I'm back at square one where I don't know what's going on with me. That's going to be an online investigation that my doctors are going to be getting into just to find out what has been going on since 2021."
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