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Friday, September 25, 2026

Week 3 NFL score predictions, picks, odds: Advanced model reveals projections for every game

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Make NFL best bets at NFL betting sites by seeing NFL score predictions from our advanced model

• 4 min read

The Week 3 NFL schedule is loaded, and you can make a great week of football even better by using the best sportsbook promos to earn up to $3,000 in sign-up bonuses from top betting apps. According to the latest NFL odds, the Rams are 2.5-point road favorites against the Broncos on Sunday Night Football. The SportsLine Projection Model simplifies NFL betting with Week 3 NFL score predictions and NFL picks for all 15 remaining NFL games by simulating each matchup 10,000 times. Bet on NFL Week 3 with the FanDuel promo code and get $250 in bonus bets:

New users can get the latest DraftKings promo code, which offers $150 in bonus bets after your first $5 bet right here:  

Bet on the NFL with the BetMGM bonus code CBSSPORTS for up to $1,500 in bonus bets:

Week 3 NFL betting promos and bonus codes 

BrandOfferCBS Promo Code
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CaesarsUp to $250 in bonuses as five days of $50 bet resetsCBSSPORTSBR250

Week 3 NFL score predictions

Sunday, Sept. 27

Bills (-7) vs. Chargers, 1 p.m. ET

Score prediction: Bills 31, Chargers 21

SportsLine predicts that the Bills cover as 7-point favorites in 55% of simulations. Claim the Fanatics Sportsbook promo code here to get $350 in FanCash:

Browns vs. Panthers (-2.5), 1 p.m. ET

Score prediction: Panthers 24, Browns 21

SportsLine predicts that the Panthers cover as 2.5-point favorites in 52% of simulations. Bet on the NFL with the BetMGM bonus code CBSSPORTS for up to $1,500 in bonus bets:

Lions (-6.5) vs. Jets, 1 p.m. ET

Score prediction: Lions 36, Jets 23

SportsLine predicts that the Lions cover as 6.5-point favorites in 66% of simulations. Claim the Caesars Sportsbook promo code CBSSPORTSBR250 and get up to $250 in bonuses as five days of $50 bet resets here:

Colts vs. Texans (-2.5), 1 p.m. ET

Score prediction: Texans 24, Colts 23

SportsLine predicts that the Colts cover as 2.5-point underdogs in 51% of simulations. Claim $200 in bonus bets with a $10 bet by signing up for the bet365 promo code CBSBET365:

Dolphins vs. Chiefs (-11.5), 1 p.m. ET

Score prediction: Chiefs 32, Dolphins 16

SportsLine predicts that the Chiefs cover as 11.5-point favorites in 60% of simulations. Bet on the NFL by claiming the latest DraftKings promo code, where new users get $150 in bonus bets after your first $5 wager: 

Giants (-2.5) vs. Titans, 1 p.m. ET

Score prediction: Giants 22, Titans 21

SportsLine predicts that the Titans cover as 2.5-point underdogs in 52% of simulations. Sign up at Hard Rock Bet and get $100 in bonus bets:

Steelers vs. Bengals (-3.5), 1 p.m. ET

Score prediction: Bengals 23, Steelers 20

SportsLine predicts that the Steelers cover as 3.5-point underdogs in 52% of simulations. Use the FanDuel promo code to get $250 in bonus bets for NFL games:

Commanders vs. Seahawks (-7), 1 p.m. ET

Score prediction: Seahawks 32, Commanders 17

SportsLine predicts that the Seahawks cover as 7-point favorites in 64% of simulations. Claim the Caesars Sportsbook promo code CBSSPORTSBR250 and get up to $250 in bonuses as five days of $50 bet resets here:

Jaguars (-2.5) vs. Patriots, 1 p.m. ET

Score prediction: Jaguars 25, Patriots 20

SportsLine predicts that the Jaguars cover as 2.5-point favorites in 53% of simulations. Bet on the NFL by claiming the latest DraftKings promo code, where new users get $150 in bonus bets after your first $5 wager: 

49ers (-8.5) vs. Cardinals, 4:05 p.m. ET

Score prediction: 49ers 31, Cardinals 20

SportsLine predicts that the 49ers cover as 8.5-point favorites in 56% of simulations. Bet on the NFL with the BetMGM bonus code CBSSPORTS for up to $1,500 in bonus bets:

Buccaneers vs. Vikings (-1.5), 4:05 p.m. ET

Score prediction: Vikings 24, Buccaneers 22

SportsLine predicts that the Vikings cover as 1.5-point favorites in 52% of simulations. Claim $200 in bonus bets with a $10 bet by signing up for bet365 Sportsbook with the promo code CBSBET365:

Cowboys vs. Ravens (-3.5), 4:25 p.m. ET

Score prediction: Ravens 31, Cowboys 29

SportsLine predicts that the Cowboys cover as 3.5-point underdogs in 53% of simulations. Claim the Fanatics Sportsbook promo code here to get $350 in FanCash:

Saints (-3) vs. Raiders, 4:25 p.m. ET  

Score prediction: Saints 27, Raiders 19

SportsLine predicts that the Saints cover as 3-point favorites in 57% of simulations. Claim the Fanatics Sportsbook promo code here to get $350 in FanCash:

Broncos vs. Rams (-2.5), 8:20 p.m. ET

Score prediction: Rams 22, Broncos 21

SportsLine predicts that the Broncos cover as 2.5-point underdogs in 54% of simulations. Use the FanDuel promo code to get $250 in bonus bets for NFL games:

Monday, Sept. 28 

Bears vs. Eagles (-4.5), 8:15 p.m. ET

Score prediction: Eagles 22, Bears 17

SportsLine predicts that the Eagles cover as 4.5-point favorites in 50% of simulations. Bet on the NFL by claiming the latest DraftKings promo code, where new users get $150 in bonus bets after your first $5 wager: 

Responsible Gaming

Every bettor should practice responsible gaming whenever placing wagers, regardless of your experience level. All the top sportsbooks offer ways to assist bettors, be it gaming limits, activity alerts, live chat options or timeout and self-exclusion measures. Sportsbooks also provide contact information for local and national helplines, including 1-800-MY-RESET, which bettors can call or text 24/7.  

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