England vs Spain betting preview with prediction, tips and best odds

• Under 4.5 goals and BTTS - 11/10 Sky Bet
• Spain to win by one goal - 10/3 Bet365

England face the reigning world champions Spain in the first game of their Nations League A campaign on Saturday, welcoming this summer’s World Cup winners to Wembley.

The Three Lions finished third at the World Cup, missing out on the final which was won in extra time by Spain against Argentina.

Spain have reached the last two finals of the Nations League - losing just two games in 18 fixtures, including the 2025 Nations League final to rivals Portugal.

Since finishing third in the inaugural edition of the competition in 2019, England have struggled in the Nations League - dropping from the elite tier and into Nations League B in 2023.

England managed to win promotion in 2024, putting them back into the mix with Europe’s top countries.

Spain are the favourites to win the Nations League - most betting sites price the world champions at 3/1 - while England have been given odds of 9/2 by UK operators, who rank the Three Lions’ chances behind France (roughly 11/4) and in-line with Germany (also roughly 9/2).

Football betting sites doubt England’s home advantage will be enough to beat the Spaniards on Saturday though, with the World Cup winners clear favourites for the win.

England are priced roughly at 2/1, with Spain rated 6/4, while odds on a draw float around 13/5.

England vs Spain prediction 1: Under 4.5 goals, Both Teams to Score

England’s last game featured 10 goals in a bizarre end to their World Cup campaign - a 6-4 win over France in the third-place play-off.

Spain conceded just once on their route to glory in America, although their Nations League campaign in 2024 and 2025 saw both teams score in seven of their 10 fixtures.

Tournament football is very different to the Nations League, which sits between a glorified friendly and the competitiveness of qualification campaigns for major tournaments.

As such, we think there will be goals in these games, but Spain’s defensive ability should keep the score relatively low.

Priced at slightly better than evens, there is some margin here - a high-scoring draw at 2-2 would still see the bet win, for example.

The added risk takes BTTS odds - roughly 4/6 with leading betting apps - and provides enough reward to make it worth it.

Sky Bet are offering the best odds on this selection and they also have betting sign up offers specific to the game.

Tip: Under 4.5 goals and BTTS - 11/10 Sky Bet

England vs Spain prediction 2: Spain to win by one goal

Spain have not lost an international game inside 90 minutes since a friendly against Colombia in 2024 - a run of 38 games.

In those 38 games they have lost just once - on penalties to Portugal in the 2025 Nations League final - so it’s easy to see why the bookies fancy the world champions at Wembley.

However, we don’t expect them to win by a landslide. Spain have won seven of their last 22 competitive fixtures by a single goal.

And, similarly, England’s only two defeats in 2026 - a loss at Wembley to Japan followed by the World Cup semi-final defeat - were by a single-goal margin.

Expect those trends to continue this weekend, with Spain edging a tight affair.

Tip: Spain to win by one goal - 10/3 Bet365

England vs Spain predicted lineups

England: Pickford; Quansah, Konsa, Guehi, O’Reilly; Anderson, Scott; Saka, Bellingham, Gordon; Kane.

Spain: Simon; Garcia, Cubarsi, Laporte, Cucurella; Rodri, Pedri; Yamal, Olmo, Nico Williams; Oyarzabal.

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