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Monday, September 21, 2026

CFB top 25 betting lines: Texas favored at Tennessee; Oregon favored at USC

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No. 1 Texas faces its next big challenge of the season on Saturday, playing at No. 14 Tennessee, and that's just one of many compelling matchups around college football in Week 4.

No. 4 Ole Miss hits the road for a big game at No. 21 Florida. No. 10 LSU looks to rebound from the emotional loss to the Rebels on Saturday, facing No. 23 Texas A&M in Baton Rouge. No. 18 Michigan welcomes No. 17 Iowa to the Big House. And No. 20 Oregon heads to Los Angeles to face No. 12 USC.

Here are the lines for all the games involving teams in the top 25.

All times Eastern. Odds by DraftKings and subject to change.

Northwestern at No. 5 Indiana -21
Friday, 8 p.m., FOX

Records: Northwestern 2-0, 0-0 vs. AP Top 25; Indiana 3-0, 0-0 vs. AP Top 25
Line Movement Alert: Opened Indiana -23.5, O/U 47.5
Money line: Northwestern (+950); Indiana (-1650)
Over/Under: 49.5 (O -115, U -105)

FPI Projection Indiana by 18.3 points with a 90% probability to win game outright

No. 1 Texas -3.5 at No. 14 Tennessee
Saturday, Noon, ABC

Records: Texas 3-0, 1-0 vs. AP Top 25; Tennessee 3-0, 0-0 vs. AP Top 25
Line Movement Alert: Opened Texas -7, O/U 56.5
Money line: Texas (-185); Tennessee (+154)
Over/Under: 56.5 (O -108, U -112)

FPI Projection Texas by 7.2 points with a 70% probability to win game outright

Illinois at No. 7 Ohio State -27.5
Saturday, Noon, FOX

Records: Illinois 2-1, 0-0 vs. AP Top 25; Ohio State 2-1, 0-1 vs. AP Top 25
Opening Line: Ohio State -27.5, O/U 54.5
Money line: Illinois (+1600); Ohio State (-4000)
Over/Under: 53.5 (O -112, U -108)

FPI Projection Ohio State by 25.6 points with a 95% probability to win game outright

Idaho at No. 11 Texas Tech -35.5
Saturday, Noon, TNT

Records: Sam Houston 1-2, 0-0 vs. AP Top 25; Texas Tech 3-0, 1-0 vs. AP Top 25
Opening Line: Texas Tech -37.5, O/U 54.5
Money line: Sam Houston (+--); Texas Tech (+--)
Over/Under: 54.5 (O -115, U -105)

FPI Projection Texas Tech by 28.6 points with a 97% probability to win game outright

Wake Forest at No. 16 Louisville -12.5
Saturday, Noon, ESPN

Records: Wake Forest 2-1, 0-1 vs. AP Top 25; Louisville 2-1, 1-1 vs. AP Top 25
Opening Line: Louisville -13.5, O/U 58.5
Money line: Wake Forest (+380); Louisville (-500)
Over/Under: 58.5 (O -105, U -115)

FPI Projection Louisville by 11.9 points with a 80% probability to win game outright

No. 3 Notre Dame -27.5 at Purdue
Saturday, 2 p.m., Peacock

Records: Notre Dame 3-0, 0-0 vs. AP Top 25; Purdue 1-2, 0-0 vs. AP Top 25
Opening Line: Notre Dame -27.5, O/U 56.5
Money line: Notre Dame (-3600); Purdue (+1500)
Over/Under: 57.5 (O -112, U -108)

FPI Projection Notre Dame by 27.9 points with a 96% probability to win game outright

Oklahoma at No. 2 Georgia -14
Saturday, 3:30 p.m., ESPN

Records: Oklahoma 2-1, 0-0 vs. AP Top 25; Georgia 3-0, 0-0 vs. AP Top 25
Line Movement Alert: Opened Georgia -10, O/U 52.5
Money line: Oklahoma (+455); Georgia (-625)
Over/Under: 43.5 (O -110, U -110)

FPI Projection Georgia by 13.8 points with a 83% probability to win game outright

No. 4 Ole Miss at No. 21 Florida -3
Saturday, 3:30 p.m., ABC

Records: Ole Miss 3-0, 2-0 vs. AP Top 25; Florida 3-0, 0-0 vs. AP Top 25
Opening Line: Florida -1.5, O/U 57.5
Money line: Ole Miss (+136); Florida (-162)
Over/Under: 60.5 (O -115, U -105)

FPI Projection Florida by 1.1 points with a 53% probability to win game outright

No. 15 Utah -7.5 at Iowa State
Saturday, 3:30 p.m., FOX

Records: Utah 3-0, 0-0 vs. AP Top 25; Iowa State 2-1, 0-1 vs. AP Top 25
Line Movement Alert: Opened Utah -11.5, O/U 49.5
Money line: Utah (-360); Iowa State (+285)
Over/Under: 49.5 (O -105, U -115)

FPI Projection Utah by 9.8 points with a 76% probability to win game outright

No. 17 Iowa at No. 18 Michigan -4.5
Saturday, 3:30 p.m., CBS

Records: Iowa 3-0, 0-0 vs. AP Top 25; Michigan 3-0, 1-0 vs. AP Top 25
Opening Line: Michigan -4.5, O/U 39.5
Money line: Iowa (+170); Michigan (-205)
Over/Under: 38.5 (O -108, U -112)

FPI Projection Michigan by 5.3 points with a 65% probability to win game outright

No. 25 Houston -17.5 at Georgia Southern
Saturday, 4 p.m., ESPNU

Records: Houston 2-1, 0-1 vs. AP Top 25; Georgia Southern 1-2, 0-0 vs. AP Top 25
Opening Line: Houston -19.5, O/U 55.5
Money line: Houston (-950); Georgia Southern (+625)
Over/Under: 54.5 (O -120, U 100)

FPI Projection Houston by 16.9 points with a 88% probability to win game outright

Wisconsin at No. 13 Penn State -10
Saturday, 5 p.m., Peacock

Records: Wisconsin 2-1, 0-1 vs. AP Top 25; Penn State 3-0, 0-0 vs. AP Top 25
Opening Line: Penn State -11.5, O/U 42.5
Money line: Wisconsin (+295); Penn State (-375)
Over/Under: 45.5 (O -112, U -108)

FPI Projection Penn State by 16.7 points with a 88% probability to win game outright

Central Michigan at No. 6 Miami -41.5
Saturday, 6:30 p.m., CW

Records: Central Michigan 2-1, 0-0 vs. AP Top 25; Miami 3-0, 0-0 vs. AP Top 25
Opening Line: Miami -42.5, O/U 54.5
Money line: Central Michigan (+--); Miami (+--)
Over/Under: 53.5 (O -110, U -110)

FPI Projection Miami by 45.7 points with a >99% probability to win game outright

South Carolina at No. 8 Alabama -13.5
Saturday, 7 p.m., ESPN

Records: South Carolina 2-1, 0-0 vs. AP Top 25; Alabama 3-0, 0-0 vs. AP Top 25
Opening Line: Alabama -11.5, O/U 46.5
Money line: South Carolina (+400); Alabama (-535)
Over/Under: 54.5 (O -115, U -105)

FPI Projection Alabama by 13 points with a 82% probability to win game outright

No. 23 Texas A&M at No. 10 LSU -9.5
Saturday, 7:30 p.m., ABC

Records: Texas A&M 2-1, 0-0 vs. AP Top 25; LSU 2-1, 0-1 vs. AP Top 25
Line Movement Alert: Opened LSU -3, O/U 57.5
Money line: Texas A&M (+300); LSU (-380)
Over/Under: 52.5 (O -112, U -108)

FPI Projection LSU by 4.5 points with a 63% probability to win game outright

No. 20 Oregon -3 at No. 12 USC
Saturday, 7:30 p.m., NBC

Records: Oregon 2-1, 0-0 vs. AP Top 25; USC 4-0, 0-0 vs. AP Top 25
Line Movement Alert: Opened Oregon -5.5, O/U 58.5
Money line: Oregon (-142); USC (+120)
Over/Under: 62.5 (O -108, U -112)

FPI Projection Oregon by 1.4 points with a 54% probability to win game outright

No. 19 Missouri at No. 24 Mississippi State -6
Saturday, 7:45 p.m., SEC Network

Records: Missouri 3-0, 0-0 vs. AP Top 25; Mississippi State 3-0, 0-0 vs. AP Top 25
Line Movement Alert: Opened Mississippi State -1.5, O/U 56.5
Money line: Missouri (+170); Mississippi State (-205)
Over/Under: 59.5 (O -105, U -115)

FPI Projection Mississippi State by 6.2 points with a 67% probability to win game outright

Missouri State at No. 22 SMU -34.5
Saturday, 9 p.m., ACC Network

Records: Missouri State 1-2, 0-1 vs. AP Top 25; SMU 2-1, 0-1 vs. AP Top 25
Opening Line: SMU -34.5, O/U 59.5
Money line: Missouri State (+3000); SMU (-10000)
Over/Under: 58.5 (O -108, U -112)

FPI Projection SMU by 29.4 points with a 97% probability to win game outright

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